Episode 336 of This American Life ("Who Can You Save?") contained an excerpt from the show Radio Lab from New York Public Radio. The TAL web site calls Radio Lab "arguably the most groundbreaking new show in public radio." That could be; it's certainly very good. It's a little like This American Life, but with an emphasis on science.
Like This American Life, a podcast of Radio Lab is available. My favorite episode (so far) is "Memory and Forgetting" (which I gave a rare 5 star rating in iTunes).